Tampa Bay Rays vs. St. Louis Cardinals

St. Louis; Thursday, 4:15 p.m. EDT

PITCHING PROBABLES: Rays: Drew Rasmussen (0-0); Cardinals: Matthew Liberatore (0-0)

BETMGM SPORTSBOOK LINE: Rays -125, Cardinals +105; over/under is 7 1/2 runs

BOTTOM LINE: The St. Louis Cardinals host the Tampa Bay Rays for the season opener.

St. Louis had a 78-84 record overall and a 44-37 record in home games last season. The Cardinals pitching staff had a collective 4.29 ERA while averaging 7.6 strikeouts per nine innings in the 2025 season.

Tampa Bay had a 77-85 record overall and a 36-45 record in road games last season. The Rays slugged .401 as a team last season with 2.7 extra base hits per game.

INJURIES: Cardinals: Hunter Dobbins: 15-Day IL (knee), Lars Nootbaar: 60-Day IL (heels)

Rays: Steven Wilson: 60-Day IL (back), Edwin Uceta: 15-Day IL (shoulder), Gavin Lux: 10-Day IL (shoulder), Ryan Pepiot: 15-Day IL (hip), Manuel Rodriguez: 60-Day IL (elbow), Taylor Walls: 10-Day IL (oblique)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Cleveland Guardians vs. Seattle Mariners

Seattle; Thursday, 10:10 p.m. EDT

PITCHING PROBABLES: Guardians: Tanner Bibee (0-0); Mariners: Logan Gilbert (0-0)

BETMGM SPORTSBOOK LINE: Mariners -188, Guardians +157; over/under is 6 1/2 runs

BOTTOM LINE: The Seattle Mariners host the Cleveland Guardians for the season opener.

Seattle had a 90-72 record overall and a 51-30 record at home last season. The Mariners averaged 8.3 hits per game last season while batting a collective .244.

Cleveland had an 88-74 record overall and a 43-38 record on the road last season. The Guardians averaged 2.6 extra base hits per game, including 1.0 home run.

INJURIES: Mariners: Miles Mastrobuoni: 10-Day IL (calf), J.P. Crawford: 10-Day IL (shoulder), Bryce Miller: 15-Day IL (oblique), Logan Evans: 60-Day IL (arm)

Guardians: George Valera: 10-Day IL (calf), Andrew Walters: 15-Day IL (lat), Hunter Gaddis: 15-Day IL (forearm)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Arizona Diamondbacks vs. Los Angeles Dodgers

Los Angeles; Thursday, 8:30 p.m. EDT

PITCHING PROBABLES: Diamondbacks: Zac Gallen (0-0); Dodgers: Yoshinobu Yamamoto (0-0)

BETMGM SPORTSBOOK LINE: Dodgers -254, Diamondbacks +206; over/under is 9 runs

BOTTOM LINE: The Los Angeles Dodgers start the season at home against the Arizona Diamondbacks.

Los Angeles went 93-69 overall and 52-29 in home games last season. The Dodgers averaged 3.2 extra base hits per game, including 1.5 home runs.

Arizona went 80-82 overall and 37-44 in road games last season. The Diamondbacks averaged 8.5 hits per game in the 2025 season with 3.3 extra base hits per game.

INJURIES: Dodgers: Jake Cousins: 15-Day IL (elbow), Gavin Stone: 15-Day IL (shoulder), Landon Knack: 15-Day IL (undisclosed), Bobby Miller: 60-Day IL (shoulder), Brusdar Graterol: 15-Day IL (shoulder), Brock Stewart: 15-Day IL (shoulder), Tommy Edman: 10-Day IL (ankle), Blake Snell: 15-Day IL (shoulder), Kike Hernandez: 60-Day IL (elbow), Evan Phillips: 60-Day IL (elbow)

Diamondbacks: Tyler Locklear: 10-Day IL (elbow), Blake Walston: 60-Day IL (elbow), Cristian Mena: 60-Day IL (shoulder), Lourdes Gurriel Jr.: 10-Day IL (knee), Adrian Del Castillo: 10-Day IL (calf), A.J. Puk: 60-Day IL (elbow), Merrill Kelly: 15-Day IL (back), Andrew Saalfrank: 60-Day IL (shoulder), Corbin Burnes: 60-Day IL (elbow), Justin Martinez: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Los Angeles Angels vs. Houston Astros

Houston; Thursday, 4:10 p.m. EDT

PITCHING PROBABLES: Angels: Jose Soriano (0-0); Astros: Hunter Brown (0-0)

BETMGM SPORTSBOOK LINE: Astros -182, Angels +151; over/under is 8 runs

BOTTOM LINE: The Houston Astros host the Los Angeles Angels in the season opener.

Houston went 87-75 overall and 46-35 in home games last season. The Astros scored 4.2 runs per game in the 2025 season while allowing 4.1.

Los Angeles had a 72-90 record overall and a 33-48 record in road games last season. The Angels scored 4.2 runs per game while allowing 5.2 last season.

INJURIES: Astros: Brandon Walter: 60-Day IL (elbow), Nate Pearson: 15-Day IL (elbow), Zach Dezenzo: 10-Day IL (elbow), Ronel Blanco: 15-Day IL (elbow), Bennett Sousa: 15-Day IL (oblique), Enyel De Los Santos: 15-Day IL (knee), Josh Hader: 15-Day IL (biceps), Hayden Wesneski: 15-Day IL (elbow)

Angels: Kirby Yates: 15-Day IL (knee), Robert Stephenson: 60-Day IL (elbow), Vaughn Grissom: 10-Day IL (hand), Grayson Rodriguez: 15-Day IL (arm), Ben Joyce: 15-Day IL (shoulder), Anthony Rendon: 60-Day IL (hip), Alek Manoah: 15-Day IL (finger)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Washington Nationals vs. Chicago Cubs

Chicago; Thursday, 2:20 p.m. EDT

PITCHING PROBABLES: Nationals: Cade Cavalli (0-0); Cubs: Matthew Boyd (0-0)

BETMGM SPORTSBOOK LINE: Cubs -230, Nationals +189; over/under is 8 runs

BOTTOM LINE: The Chicago Cubs open the season at home against the Washington Nationals.

Chicago had a 92-70 record overall and a 50-31 record at home last season. The Cubs scored 4.9 runs per game while giving up 4.0 in the 2025 season.

Washington went 66-96 overall and 34-47 on the road a season ago. The Nationals scored 4.2 runs per game in the 2025 season while giving up 5.5.

INJURIES: Cubs: Porter Hodge: 15-Day IL (elbow), Seiya Suzuki: 10-Day IL (knee), Justin Steele: 60-Day IL (elbow), Jordan Wicks: 15-Day IL (forearm), Shelby Miller: 60-Day IL (elbow), Christopher Austin: 60-Day IL (knee)

Nationals: Trevor Williams: 60-Day IL (elbow), Josiah Gray: 60-Day IL (elbow), Paxton Schultz: 15-Day IL (elbow), DJ Herz: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Minnesota Twins vs. Baltimore Orioles

Baltimore; Thursday, 3:05 p.m. EDT

PITCHING PROBABLES: Twins: Joe Ryan (0-0); Orioles: Trevor Rogers (0-0)

BETMGM SPORTSBOOK LINE: Orioles -139, Twins +118; over/under is 8 runs

BOTTOM LINE: The Baltimore Orioles host the Minnesota Twins in the season opener.

Baltimore went 75-87 overall and 39-42 in home games a season ago. The Orioles pitching staff had a collective 4.61 ERA while averaging 8.5 strikeouts per nine innings in the 2025 season.

Minnesota had a 70-92 record overall and a 32-49 record on the road last season. The Twins averaged 8.0 hits per game last season while batting a collective .238.

INJURIES: Orioles: Jordan Westburg: 10-Day IL (ucl), Jackson Holliday: 10-Day IL (finger), Heston Kjerstad: 10-Day IL (hamstring), Keegan Akin: 15-Day IL (groin), Andrew Kittredge: 15-Day IL (shoulder), Felix Bautista: 60-Day IL (shoulder), Colin Selby: 60-Day IL (shoulder)

Twins: David Festa: 15-Day IL (shoulder), Travis Adams: 15-Day IL (tricep), Pablo Lopez: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Detroit Tigers vs. San Diego Padres

San Diego; Thursday, 4:10 p.m. EDT

PITCHING PROBABLES: Tigers: Tarik Skubal (0-0); Padres: Nick Pivetta (0-0)

BETMGM SPORTSBOOK LINE: Tigers -131, Padres +110; over/under is 7 runs

BOTTOM LINE: The San Diego Padres host the Detroit Tigers in the season opener.

San Diego had a 90-72 record overall and a 52-29 record in home games last season. The Padres pitching staff had a 3.63 ERA collectively last season while averaging 9.0 strikeouts and 3.4 walks per nine innings.

Detroit went 87-75 overall and 41-40 in road games last season. The Tigers pitching staff averaged 8.6 strikeouts per nine innings while giving up 4.3 runs per game in the 2025 season.

INJURIES: Padres: Bryan Hoeing: 15-Day IL (elbow), Jason Adam: 15-Day IL (quadricep), Yuki Matsui: 15-Day IL (groin), Matt Waldron: 15-Day IL (lower body), Joe Musgrove: 15-Day IL (elbow), Griffin Canning: 15-Day IL (achilles), Will Wagner: 10-Day IL (oblique), Sung-Mun Song: 10-Day IL (oblique), Jhony Brito: 60-Day IL (elbow)

Tigers: Trey Sweeney: 10-Day IL (shoulder), Bailey Horn: 15-Day IL (elbow), Sawyer Gipson-Long: 15-Day IL (oblique), Reese Olson: 60-Day IL (shoulder), Jackson Jobe: 60-Day IL (elbow), Troy Melton: 60-Day IL (elbow), Beau Brieske: 60-Day IL (groin)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Boston Red Sox vs. Cincinnati Reds

Cincinnati; Thursday, 4:10 p.m. EDT

PITCHING PROBABLES: Red Sox: Garrett Crochet (0-0); Reds: Andrew Abbott (0-0)

BETMGM SPORTSBOOK LINE: Red Sox -160, Reds +135; over/under is 8 runs

BOTTOM LINE: The Cincinnati Reds open the season at home against the Boston Red Sox.

Cincinnati went 83-79 overall and 45-36 at home a season ago. The Reds averaged 8.2 hits per game last season while batting a collective .245 and slugging .391.

Boston had an 89-73 record overall and a 41-40 record on the road last season. The Red Sox slugged .421 with a .745 OPS as a team in the 2025 season.

INJURIES: Reds: Caleb Ferguson: 15-Day IL (oblique), Hunter Greene: 60-Day IL (elbow), Nick Lodolo: 15-Day IL (finger)

Red Sox: Patrick Sandoval: 15-Day IL (elbow), Kutter Crawford: 15-Day IL (wrist), Anthony Seigler: 10-Day IL (knee), Romy Gonzalez: 60-Day IL (shoulder), Triston Casas: 10-Day IL (knee), Tanner Houck: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Chicago White Sox vs. Milwaukee Brewers

Milwaukee; Thursday, 2:10 p.m. EDT

PITCHING PROBABLES: White Sox: Shane Smith (0-0); Brewers: Jacob Misiorowski (0-0)

BETMGM SPORTSBOOK LINE: Brewers -186, White Sox +155; over/under is 8 runs

BOTTOM LINE: The Milwaukee Brewers host the Chicago White Sox for the season opener.

Milwaukee went 97-65 overall and 52-29 in home games last season. The Brewers scored 5.0 runs per game in the 2025 season while giving up 3.9.

Chicago had a 60-102 record overall and a 27-54 record on the road last season. The White Sox slugged .373 with a .675 OPS as a team in the 2025 season.

INJURIES: Brewers: Steward Berroa: 10-Day IL (shoulder), Craig Yoho: 15-Day IL (calf), Rob Zastryzny: 15-Day IL (shoulder), Quinn Priester: 15-Day IL (wrist), Akil Baddoo: 60-Day IL (quadricep)

White Sox: Kyle Teel: 10-Day IL (hamstring), Drew Thorpe: 15-Day IL (elbow), Brooks Baldwin: 10-Day IL (elbow), Mike Vasil: 15-Day IL (elbow), Prelander Berroa: 15-Day IL (elbow), Ky Bush: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Texas Rangers vs. Philadelphia Phillies

Philadelphia; Thursday, 4:15 p.m. EDT

PITCHING PROBABLES: Rangers: Nathan Eovaldi (0-0); Phillies: Cristopher Sanchez (0-0)

BETMGM SPORTSBOOK LINE: Phillies -158, Rangers +133; over/under is 8 runs

BOTTOM LINE: The Philadelphia Phillies host the Texas Rangers for the season opener.

Philadelphia had a 96-66 record overall and a 55-26 record in home games last season. The Phillies pitching staff averaged 9.2 strikeouts per nine innings while giving up 4.0 runs per game in the 2025 season.

Texas went 81-81 overall and 33-48 on the road a season ago. The Rangers averaged 7.9 hits per game last season and totaled 175 home runs.

INJURIES: Phillies: Zack Wheeler: 15-Day IL (shoulder), Max Lazar: 15-Day IL (oblique), Orion Kerkering: 15-Day IL (hamstring)

Rangers: Jordan Montgomery: 60-Day IL (elbow), Cody Freeman: 10-Day IL (back ), Cody Bradford: 15-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.