Cleveland Guardians (3-3) vs. Los Angeles Dodgers (4-1)

Los Angeles; Wednesday, 8:20 p.m. EDT

PITCHING PROBABLES: Guardians: Gavin Williams (0-1, 5.40 ERA, 1.60 WHIP, seven strikeouts); Dodgers: Yoshinobu Yamamoto (1-0, 3.00 ERA, 0.83 WHIP, six strikeouts)

BETMGM SPORTSBOOK LINE: Dodgers -265, Guardians +215; over/under is 8 1/2 runs

BOTTOM LINE: The Los Angeles Dodgers and Cleveland Guardians meet on Wednesday with the winner claiming the three-game series.

Los Angeles went 93-69 overall and 52-29 in home games last season. The Dodgers batted .253 as a team in the 2025 season with a .768 OPS.

Cleveland went 88-74 overall and 43-38 on the road a season ago. The Guardians batted .226 as a team in the 2025 season with a .670 OPS.

INJURIES: Dodgers: Jake Cousins: 15-Day IL (elbow), Gavin Stone: 15-Day IL (shoulder), Landon Knack: 15-Day IL (undisclosed), Bobby Miller: 60-Day IL (shoulder), Brusdar Graterol: 15-Day IL (shoulder), Brock Stewart: 15-Day IL (shoulder), Tommy Edman: 10-Day IL (ankle), Blake Snell: 15-Day IL (shoulder), Kike Hernandez: 60-Day IL (elbow), Evan Phillips: 60-Day IL (elbow)

Guardians: Chase DeLauter: day-to-day (foot), George Valera: 10-Day IL (calf), Andrew Walters: 15-Day IL (lat), Hunter Gaddis: 15-Day IL (forearm)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Minnesota Twins (1-3) vs. Kansas City Royals (2-2)

Kansas City, Missouri; Wednesday, 7:40 p.m. EDT

PITCHING PROBABLES: Twins: Joe Ryan (0-0, 0.00 ERA, 0.56 WHIP, seven strikeouts); Royals: Noah Cameron (0-0)

BETMGM SPORTSBOOK LINE: Twins -121, Royals +101; over/under is 8 1/2 runs

BOTTOM LINE: The Kansas City Royals face the Minnesota Twins, leading the series 1-0.

Kansas City went 82-80 overall and 43-38 at home a season ago. The Royals pitching staff had a collective 3.74 ERA while averaging 8.0 strikeouts per nine innings in the 2025 season.

Minnesota had a 70-92 record overall and a 32-49 record on the road last season. The Twins pitching staff averaged 8.7 strikeouts per nine innings while giving up 4.8 runs per game in the 2025 season.

INJURIES: Royals: Stephen Kolek: 15-Day IL (oblique), James McArthur: 15-Day IL (elbow), Michael Massey: 10-Day IL (calf), Alec Marsh: 60-Day IL (shoulder)

Twins: David Festa: 15-Day IL (shoulder), Travis Adams: 15-Day IL (tricep), Pablo Lopez: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

New York Yankees (4-1) vs. Seattle Mariners (3-3)

Seattle; Wednesday, 4:10 p.m. EDT

PITCHING PROBABLES: Yankees: Cam Schlittler (1-0, 0.00 ERA, 0.19 WHIP, eight strikeouts); Mariners: George Kirby (1-0, 1.50 ERA, 0.67 WHIP, six strikeouts)

BETMGM SPORTSBOOK LINE: Yankees -115, Mariners -102; over/under is 7 runs

BOTTOM LINE: The Seattle Mariners and New York Yankees play on Wednesday with the winner claiming the three-game series.

Seattle had a 90-72 record overall and a 51-30 record in home games last season. The Mariners slugged .420 as a team last season with 3.0 extra base hits per game.

New York had a 94-68 record overall and a 44-37 record on the road last season. The Yankees scored 5.2 runs per game while giving up 4.2 in the 2025 season.

INJURIES: Mariners: Carlos Vargas: 15-Day IL (lat), Miles Mastrobuoni: 10-Day IL (calf), J.P. Crawford: 10-Day IL (shoulder), Bryce Miller: 15-Day IL (oblique), Logan Evans: 60-Day IL (arm)

Yankees: Gerrit Cole: 15-Day IL (elbow), Carlos Rodon: 15-Day IL (elbow), Clarke Schmidt: 60-Day IL (elbow), Anthony Volpe: 10-Day IL (shoulder)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Detroit Tigers (2-3) vs. Arizona Diamondbacks (2-3)

Phoenix; Wednesday, 3:40 p.m. EDT

PITCHING PROBABLES: Tigers: Tarik Skubal (1-0, 0.00 ERA, 0.50 WHIP, six strikeouts); Diamondbacks: Zac Gallen (0-1, 9.00 ERA, 1.75 WHIP, two strikeouts)

BETMGM SPORTSBOOK LINE: Diamondbacks -110, Tigers -110; over/under is 9 1/2 runs

BOTTOM LINE: The Detroit Tigers, on a three-game losing streak, play the Arizona Diamondbacks.

Arizona went 80-82 overall and 43-38 at home a season ago. The Diamondbacks slugged .433 as a team in the 2025 season while hitting 1.3 home runs per game.

Detroit had an 87-75 record overall and a 41-40 record on the road last season. The Tigers averaged 3.0 extra base hits per game, including 1.2 home runs.

INJURIES: Diamondbacks: Pavin Smith: 10-Day IL (elbow), Tyler Locklear: 10-Day IL (elbow), Cristian Mena: 60-Day IL (shoulder), Lourdes Gurriel Jr.: 10-Day IL (knee), Adrian Del Castillo: 10-Day IL (calf), Blake Walston: 60-Day IL (elbow), A.J. Puk: 60-Day IL (elbow), Merrill Kelly: 15-Day IL (back), Andrew Saalfrank: 60-Day IL (shoulder), Corbin Burnes: 60-Day IL (elbow), Justin Martinez: 60-Day IL (elbow)

Tigers: Trey Sweeney: 10-Day IL (shoulder), Bailey Horn: 15-Day IL (elbow), Sawyer Gipson-Long: 15-Day IL (oblique), Reese Olson: 60-Day IL (shoulder), Jackson Jobe: 60-Day IL (elbow), Troy Melton: 60-Day IL (elbow), Beau Brieske: 60-Day IL (groin)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Boston Red Sox (1-4) vs. Houston Astros (4-2)

Houston; Wednesday, 2:10 p.m. EDT

PITCHING PROBABLES: Red Sox: Garrett Crochet (1-0, 0.00 ERA, 0.83 WHIP, eight strikeouts); Astros: Mike Burrows (0-1, 7.94 ERA, 1.94 WHIP, six strikeouts)

BETMGM SPORTSBOOK LINE: Astros -143, Red Sox +122; over/under is 7 1/2 runs

BOTTOM LINE: The Houston Astros will try to keep their four-game home win streak intact when they face the Boston Red Sox.

Houston had an 87-75 record overall and a 46-35 record in home games last season. The Astros averaged 8.5 hits per game in the 2025 season with 2.7 extra base hits per game.

Boston had an 89-73 record overall and a 41-40 record on the road last season. The Red Sox pitching staff put up a 3.71 ERA collectively last season while averaging 8.5 strikeouts and 3.3 walks per nine innings.

INJURIES: Astros: Hayden Wesneski: 60-Day IL (elbow), Brandon Walter: 60-Day IL (elbow), Nate Pearson: 15-Day IL (elbow), Zach Dezenzo: 10-Day IL (elbow), Ronel Blanco: 15-Day IL (elbow), Bennett Sousa: 15-Day IL (oblique), Enyel De Los Santos: 15-Day IL (knee), Josh Hader: 15-Day IL (biceps)

Red Sox: Patrick Sandoval: 15-Day IL (elbow), Kutter Crawford: 15-Day IL (wrist), Anthony Seigler: 10-Day IL (knee), Triston Casas: 10-Day IL (knee), Romy Gonzalez: 60-Day IL (shoulder), Tanner Houck: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Colorado Rockies (1-4) vs. Toronto Blue Jays (4-1)

Toronto; Wednesday, 1:07 p.m. EDT

PITCHING PROBABLES: Rockies: Kyle Freeland (0-1, 4.15 ERA, 1.61 WHIP, two strikeouts); Blue Jays: Kevin Gausman (0-0, 1.50 ERA, 0.17 WHIP, 11 strikeouts)

BETMGM SPORTSBOOK LINE: Blue Jays -284, Rockies +229; over/under is 8 runs

BOTTOM LINE: The Toronto Blue Jays and Colorado Rockies play on Wednesday with the three-game series tied 1-1.

Toronto had a 94-68 record overall and a 54-27 record at home last season. The Blue Jays averaged 9.0 hits per game last season while batting a collective .265.

Colorado had a 43-119 record overall and an 18-63 record in road games last season. The Rockies slugged .386 as a team in the 2025 season while hitting 1.0 home run per game.

INJURIES: Blue Jays: Cody Ponce: 15-Day IL (knee), Mason Fluharty: day-to-day (knee), Anthony Santander: 10-Day IL (shoulder), Shane Bieber: 15-Day IL (elbow), Jose Berrios: 15-Day IL (elbow), Yimi Garcia: 15-Day IL (elbow), Trey Yesavage: 15-Day IL (shoulder), Bowden Francis: 60-Day IL (elbow)

Rockies: Ryan Feltner: day-to-day (glute), Blaine Crim: 10-Day IL (oblique), Tyler Freeman: 10-Day IL (back), McCade Brown: 15-Day IL (shoulder), Mickey Moniak: 10-Day IL (finger), Zac Veen: 10-Day IL (knee), Pierson Ohl: 60-Day IL (elbow), RJ Petit: 60-Day IL (elbow), Kris Bryant: 60-Day IL (back), Jeff Criswell: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Tampa Bay Rays (2-3) vs. Milwaukee Brewers (4-1)

Milwaukee; Wednesday, 1:40 p.m. EDT

PITCHING PROBABLES: Rays: Drew Rasmussen (0-0, 1.80 ERA, 0.80 WHIP, two strikeouts); Brewers: Jacob Misiorowski (1-0, 1.80 ERA, 1.00 WHIP, 11 strikeouts)

BETMGM SPORTSBOOK LINE: Brewers -142, Rays +119; over/under is 7 runs

BOTTOM LINE: The Milwaukee Brewers and Tampa Bay Rays play on Wednesday with the winner claiming the three-game series.

Milwaukee went 97-65 overall and 52-29 in home games last season. The Brewers pitching staff had a collective 3.59 ERA last season while averaging 9.0 strikeouts and 3.3 walks per nine innings.

Tampa Bay had a 77-85 record overall and a 36-45 record in road games last season. The Rays slugged .401 with a .714 OPS as a team in the 2025 season.

INJURIES: Brewers: Andrew Vaughn: 10-Day IL (hand), Steward Berroa: 10-Day IL (shoulder), Craig Yoho: 15-Day IL (calf), Rob Zastryzny: 15-Day IL (shoulder), Jackson Chourio: 10-Day IL (hand), Quinn Priester: 15-Day IL (wrist), Akil Baddoo: 60-Day IL (quadricep)

Rays: Steven Wilson: 60-Day IL (back), Edwin Uceta: 15-Day IL (shoulder), Gavin Lux: 10-Day IL (shoulder), Ryan Pepiot: 15-Day IL (hip), Manuel Rodriguez: 60-Day IL (elbow), Taylor Walls: 10-Day IL (oblique)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Texas Rangers (4-1) vs. Baltimore Orioles (2-3)

Baltimore; Wednesday, 12:35 p.m. EDT

PITCHING PROBABLES: Rangers: Nathan Eovaldi (0-1, 9.64 ERA, 1.71 WHIP, seven strikeouts); Orioles: Trevor Rogers (1-0, 0.00 ERA, 1.00 WHIP, five strikeouts)

BETMGM SPORTSBOOK LINE: Orioles -116, Rangers -103; over/under is 8 1/2 runs

BOTTOM LINE: The Baltimore Orioles play the Texas Rangers after Taylor Ward had four hits against the Rangers on Tuesday.

Baltimore went 75-87 overall and 39-42 at home a season ago. The Orioles slugged .394 as a team in the 2025 season while hitting 1.2 home runs per game.

Texas went 81-81 overall and 33-48 on the road a season ago. The Rangers scored 4.2 runs per game in the 2025 season while giving up 3.7.

INJURIES: Orioles: Zach Eflin: 15-Day IL (elbow), Jackson Holliday: 10-Day IL (finger), Heston Kjerstad: 10-Day IL (hamstring), Keegan Akin: 15-Day IL (groin), Andrew Kittredge: 15-Day IL (shoulder), Jordan Westburg: 10-Day IL (ucl), Felix Bautista: 60-Day IL (shoulder), Colin Selby: 60-Day IL (shoulder)

Rangers: Cody Freeman: 10-Day IL (back ), Cody Bradford: 15-Day IL (elbow), Jordan Montgomery: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Chicago White Sox (1-4) vs. Miami Marlins (4-1)

Miami; Wednesday, 1:10 p.m. EDT

PITCHING PROBABLES: White Sox: Shane Smith (0-1, 16.20 ERA, 3.00 WHIP, two strikeouts); Marlins: Sandy Alcantara (1-0, 0.00 ERA, 0.86 WHIP, five strikeouts)

BETMGM SPORTSBOOK LINE: Marlins -153, White Sox +128; over/under is 7 1/2 runs

BOTTOM LINE: The Miami Marlins and Chicago White Sox meet on Wednesday with the winner claiming the three-game series.

Miami went 79-83 overall and 38-43 in home games last season. The Marlins slugged .393 with a .314 on-base percentage as a team in the 2025 season.

Chicago had a 60-102 record overall and a 27-54 record on the road last season. The White Sox scored 4.0 runs per game in the 2025 season while allowing 4.6.

INJURIES: Marlins: Christopher Morel: 10-Day IL (oblique), Esteury Ruiz: 10-Day IL (oblique), Kyle Stowers: 10-Day IL (hamstring), Adam Mazur: 60-Day IL (elbow), Max Acosta: 10-Day IL (oblique), Ronny Henriquez: 60-Day IL (elbow)

White Sox: Kyle Teel: 10-Day IL (hamstring), Drew Thorpe: 15-Day IL (elbow), Brooks Baldwin: 10-Day IL (elbow), Mike Vasil: 15-Day IL (elbow), Prelander Berroa: 15-Day IL (elbow), Ky Bush: 60-Day IL (elbow)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.